Ganoderma lucidum, is made from the Red Reishi Mushroom. It is commonly known as the Lingzi mushroom, and is frequently used in traditional Chinese medicine. It is also popular in Japanese and Korean medicine but is relatively new to Western medicine.
USES OF GANODERMA LUDICUM
To treat fatigue
To lower high cholesterol
To treat HIV and Aids.
To lower blood pressure
To stimulate the immune system
To reduce inflammation
For increased strength and stamina
To treat lower urinary tract symptons
Memorial Sloan Kettering Cancer Centre is currently studying the effects of ganoderma lucidum. Extracts of reishi were shown to have immunomodulatory renoprotective, anti-inflammatory and hepatoprotective properties both in vitro and in vivo. Clinical studies indicate its benefits in improving lower urinary tract symptoms in men, and in exerting mild antidiabetic effects and improving dyslipidemia.
It has also been studied for its anticancer potential. Studies indicate that it has antiproliferative and chemopreventive effects, alleviates chemotherapy-induced nausea, enhances the efficacy of radiotherapy, and increased the sensitivity of ovarian cancer cells to cisplatin.
In small clinical studies, reishi increased plasma antioxidant capacity, and enhances immune responses in cancer patients. In another study, a water-soluble reishi extract appeared to suppress development of colorectal adenomas. Remission of hepatocellular carcinoma (HCC) was reported in a few cases in a single study. Another case study series suggests benefits for gastrointestinal cancer patients.
Beta glucans present in reishi, have demonstrated anititumour and immunostimulating activities. Its triterpene compounds may inhibit tumour invasion and tumour metastases by limiting attachment to endothelial cells. Recent findings indicate that reishi induces natural killer cell cytotoxicity against various cancer cell lines via activation of the natural cytotoxic receptors. In human ovarian cancer cells, reishi inhibits proliferation by suppressing vascular endothelial grown factor.
In other studies reishi increased plasma antioxidant capacity and enhanced immune response in advance-stage cancer patients.
Reishi is also being studies by the U.S. Department of Defence, Bio-Sciences Division, for the treatment and prevention of viruses such as Ebola.
WHEN NOT TO TAKE IT
You are taking warfarin or other blood thinners Reishi may increase the risk of bleeding.
You are on chemotherapy. Reishi may make some chemotherapy drugs less effective.
You are using immunosuppressants. Reishi can stimulate immune responses.
If you are taking drugs that are substrates of Cytochrome P450 2E1, 1A2, and 3A. Reishi may increase the risk of side effects of these drugs.
Ganoderma has a large amount of bioactive molecules, and there is no single “one” molecule in this mushroom that can be said to be the main bioactive.
Some effects, such as improving sleep and decreasing symptoms of chronic fatigue syndrome, are not acute; sleep improvements are seen after 3 days whereas aid in chronic fatigue may take more than 4 weeks.